Posted by Dejan Stojadinovic on May 17, 2018 6:05:58 AM

This supplement will make you Bigger, Leaner, Faster and Stronger! Or will it? Nutritional supplements are a multi-million dollar industry, and chances are you, or someone you know, is taking one or more supplements to get that competitive edge. This article will help you sift through some of the evidence of “BRO SCIENCE VS ACTUAL SCIENCE - WHO IS RIGHT?” when it comes to making an informed choice about which supplements (if any) you should be taking and why.


  • Understanding why to focus on the 95% – Diet, training and lifestyle factors
  • Apply a practical nutrition pyramid for weight loss, weight gain, wellness and performance enhancement
  • Why to focus on the macros and micros (Just Eat Real Food- JERF)
  • What is nutritional periodization
  • What adaptation(s) are you looking to augment with supplementation
  • Be able to confidently recommend some evidence-based ergogenic supplements and their appropriate dosing


You may have heard the phrase “you can’t out exercise a bad diet.” Ultimately, you can’t out exercise or out supplement a bad lifestyle either. This includes: Sleep, Psychological stress, Environmental factors, Exercise and Diet. What I refer to as “SPEED.”


Exercising reaction times, vigor, fatigue and depression have all been shown to be adversely affected by sleep deprivation. (Scott, J. P. et al. 2006) According to the National Sleep Foundation, sleep is an essential part of recovery and can play a role in hormone regulation, such as cortisol, as well as having effects on glycogen production. Optimum sleep is part of what determines how quickly one can rebuild muscle and replenish nutrients, and also helps to maintain endurance, speed, and accuracy. These recommendations from the National Sleep Foundation should be the minimum. Athletes should probably aim for 8-10 hours and gauge this based on their training, mood and performance. In a study by Mah, C. D., et al., 10 hours of sleep was shown to be beneficial in reaching peak athletic performance.


Stress is a reaction by the body and brain to meet the demands of some challenge or threat. Stress hormones, such as cortisol, cross the blood-brain barrier, and if out of balance, can impair cognitive processes such as attention, memory and decision-making. It can also result in physical symptoms such as increased muscle tension, which in turn can adversely affect motor functions. Stress can interfere with both sleep quality and quantity. The combination of muscle tension and poor sleep can lead to fatigue. Stress also affects immune functioning, increasing one’s susceptibility to illnesses from viruses and bacteria, and can also have a negative effect on tissue repair. (Sapolsky, R. M. 1994)

There are a number of stress modification techniques, such as meditation and guided imagery. Repeated practice of meditation techniques has been shown to reverse the effects of chronic stress on health. In addition, mental practice is also an effective means of enhancing performance. (Driskell, J. E. et al. 1994) (MacLean, C. R. et al. 1997)


Endocrine disruptors are chemicals known to interfere with development and reproduction. They may also cause serious neurological and immune system effects. These disruptions occur because these chemicals mimic hormones in the body, including the female sex hormone estrogen, the male sex hormone androgen, and thyroid hormones. Endocrine-disrupting chemicals may block hormonal signals in the body or interfere with the way the hormones or receptors are made or controlled.

Common sources include:

  1. Personal care products
  2. Drinking water
  3. Canned foods
  4. Conventional produce
  5. CAFO (Conventional Animal Feed Operations) meat, poultry and dairy
  6. High mercury fish
  7. Kitchen products (e.g., cookware)
  8. Cleaning products
  9. Office products
  10. Cash register receipts

The Environmental Working Group is also a great resource to help address this global issue.


A sound exercise or training program is essential when it comes to performance. The NASM Optimum Performance Training ™ (OPT ™) model is an evidence-based way to maximize desired adaptations in a safe and progressive manner.

Some key points to consider when designing an exercise program include:

  • Dose
  • Acute Variables (e.g., sets, reps, rest, etc.)
  • Exercise type
  • Stable baseline before progression
  • Addressing impairments and limitations
  • Optimal loading
  • Program progression
  • Periodization

(Clark, M. A., et al. 2008)


When it comes to diet, some key considerations for optimal health, performance and recovery include:

In general, focus on vegetables, fruits, nuts and seeds, legumes, eggs, whole grains and free-range/pasture raised animals. In addition, avoid refined carbohydrates and pro-inflammatory fats (e.g., refined seed oils and trans fats) and opt for choosing local, seasonal, sustainable and organic foods. (Galland, L. 2010) (Simopoulos, A. P. 2008)


Eric Helms, a natural bodybuilder and PhD candidate, describes a pyramid approach in his book The Muscle Strength Nutrition Pyramid.

This approach prioritizes nutrition as follows:                                                                                           The Muscle Strength Nutrition Pyramid.

  1. Calories/Energy balance
  2. Macronutrients and Fiber
  3. Micronutrients and Water
  4. Nutrient Timing and Meal Frequency
  5. Supplements



  • Resting Metabolic Rate (RMR) 60%
  • Activity Energy Expenditure (AEE) 30%
  • Thermic Effect of Food (TEF) 10%

There are a number of online calculators that can help estimate RMR and AEE. These can be useful for weight gain and weight loss applications. The TEF is highest for protein and fiber, so when the desired adaptation is weight loss, aside from a calorie deficit, focusing on protein and fiber will be useful dietary strategies. Energy balance is also essential for performance sports or training where weight loss or weight gain is not the goal, but energy to perform the activity is. In these cases, sufficient calories to fuel an activity are important.

One guideline is the acronym HEC: Hunger, Energy & Emotions, Cravings. If your “HEC” is in check, you are probably energy primed for performance


Macronutrients are types of food (carbohydrates, proteins and fats) required in large amounts in the human diet.


Carbohydrates (CHO) consist of sugars, starches and fibers.

They can also be classified based on how they can influence blood sugar:

  • High Glycemic Index/ Load- rapidly increase blood glucose
  • Low Glycemic Index/Load- slow increase in blood glucose


When carbohydrate availability is low, AMPK, a metabolic sensor, stimulates the production of PGC-1α, a transcriptional co-activator that regulates gene expression and energy metabolism. This results in increased mitochondrial enzyme activities, increased lipid oxidation, lactate removal and improved exercise capacity/performance. (Liang, H., & Ward, W. F. 2006), (Knuiman, P. et al. 2015)



  • Attenuation of central fatigue
  • Maintenance of CHO oxidation rates
  • Muscle glycogen sparing
  • Reducing exercise-induced strain
  • Maintenance of excitation-contraction coupling
  • Glycogen availability to meet the needs of sprinting or higher intensity


  • DOSE= 5 – 8 g/kg of body weight (BW) for moderate intensity training and 8 -10 g/kg BW per day for high intensity
  • Carb load the day before and maintain during the event
  • Ingest 3-6 hours prior to exercise
  • Pre-Exercise: Low GI pre-exercise meal resulted in a higher rate of fat oxidation during exercise than did a high GI meal
  • Relative shift in substrate utilization from CHO to fat when a low GI meal is ingested before exercise compared with that for a high GI meal (Research shows there is no difference in endurance running capacity when focusing on lower GI carbohydrates and that this probably promotes metabolic flexibility of energy substrate utilization.)

Sources: Vegetables, fruits, grains and dairy

(Burke, Louise M. et al. 2001) (Karelis, A. D. et al. 2010) (Smith-Ryan, A., & Antonio, J. 2013)  (Stevenson, E. J. et al. 2006)


Proteins are large macromolecules of one or more long chains of amino acid residues


  • Catalyzing metabolic reactions
  • DNA replication
  • Transporting molecules
  • Muscle Protein Synthesis (MPS)- Leucine “triggers” mTOR, which in turn promotes MPS. Some studies show that Leucine + Carbohydrates augment this adaptation


  • Leucine is the key BCAA to stimulate/trigger muscle protein synthesis
  • Alternate whole meals with a leucine supplement
  • Dose: 2-3 g of leucine (25-35 g of high quality whey protein)
  • Food sources: beef, poultry, pork, lamb, fish, eggs, dairy
  • In general, plant based protein diets can impair training adaptations relative to meat and dairy diets
  • Whey: fast-digesting (consume protein close to training session)
  • Casein: slow-digesting (take before bed)

(Dreyer, H. C., Drummond, et al. 2008) (Norton, L. E., & Layman, D. K. 2006) (Smith-Ryan, A., & Antonio, J. 2013)


Fats and oils are categorized according to the number and bonding of the carbon atoms in the aliphatic chain.

Saturated fats – no double bonds

Polyunsaturated – missing several hydrogen atoms and have two or more double bonds

Unsaturated fats – one or more double bonds


  • Energy source and energy storage
  • Hormone production
  • Inflammation


Monounsaturated: Includes avocado, olive oil, macadamia nuts


  • Omega 6: includes seed and vegetable oils (e.g., canola, corn, peanut, sunflower, safflower)
  • Omega 3: includes flaxseed, walnuts, cold-water fish (e.g., salmon)
  • Omega Considerations: The SAD (Standard American Diet) is notoriously pro-inflammatory, with the omega 6:omega 3 greater than 4:1 (closer to 18:1).

Saturated: Animal products and coconut

Athletes should focus on a diet consisting of: Dark green leafy vegetables, flax/hemp seeds, walnuts cold water fish, grass-fed beef, omega-3 eggs; and limit omega-6 (vegetable and seed oils). Saturated fat should come from grass fed, pasture raised animals. (Simopoulos, A. P. 2008)



Fish oil information

(Smith-Ryan, A., & Antonio, J. 2013)


  • Fresh (low levels of peroxidation)
  • Molecularly distilled and pure (low levels of heavy metals and contaminants)
  • Third-party tested
  • Triglyceride vs ethyl esterified molecular form

DOSE: AHA recommends 1g/day for general health. To reduce soreness: 6g dose, spread over the course of a day.


Micronutrients, as opposed to macronutrients (carbohydrates, proteins and fat), are comprised of vitamins and minerals that are required in small quantities to ensure normal metabolism, growth and physical well-being.

When it comes to micronutrients I say JERF- Just Eat Real Food.

If your diet is 50-75% plant based and includes healthy fats and adequate protein, you are likely to get the vitamins, minerals and phytonutrients you need without supplementation. Eating a rainbow of foods (colorful vegetables and fruits) also helps with anti-inflammatory phytonutrients, which are rich in antioxidants to help naturally speed up the repair process

Phytonutrients, also called phytochemicals, are chemicals produced by plants. Phytonutrients can provide significant health benefits for humans who eat plant foods. Phytonutrient-rich foods include colorful fruits and vegetables, legumes, nuts, tea, cocoa, whole grains and many spices. As with other micronutrients, JERF.

Some of my favorite phytonutrients with ergogenic properties include:

Green Tea

Polyphenols known as catechins (EGCG) are abundant in green tea. Green Tea Extract (GTE) has been shown to enhance endurance by increased metabolic capacity and utilization of fatty acid as a source of energy in skeletal muscle during exercise. (Murase, T., et al. 2006) Human studies suggest that green tea may contribute to a reduction in the risk of cardiovascular disease and some forms of cancer, as well as to the promotion of oral health and other physiological functions such as anti-hypertensive effect, body weight control, antibacterial and antivirasic activity, solar ultraviolet protection, bone mineral density increase, anti-fibrotic properties, and neuroprotective power. (Cabrera, C. et al 2006)

Cocoa (Cacao)

Cocoa consumption could be useful in maintaining a good physical fitness due to the favorable effects on muscle and redox status in athletes during exhaustive exercise. (González-Garrido, J. A. et al 2015)


Nutrient timing is the application of knowing when to eat and what to eat before, during and after exercise. It is designed to help athletes, recreational competitors, and exercise enthusiasts achieve their most advantageous exercise performance and recovery. Some sources have looked at nutrient timing as a window of opportunity. In reality, it is more like a garage door.


  • Whey protein dosed at 0.4–0.5 g/kg of LBM pre- and post-exercise
  • Maximal acute anabolic effect of 20–40 g
  • Pre- and post-exercise meals every 3–4 hours
  • Carbohydrate dosage and timing relative to resistance training is a gray area. For maximizing rates of muscle gain meet total daily carbohydrate need instead of specifically timing its constituent doses

(Aragon, A. A., & Schoenfeld, B. J. 2013)

My take on nutrient timing is that immediately post-exercise there is increased blood flow and nutrient delivery. While MPS is increased for 24 hours post exercise, replacing nutrients as soon as possible is probably more ideal for a number of biochemical and physiological reasons.


  • Lean Body Mass-Strength-Power
  • Immune Health
  • Hydration
  • Cardiovascular Performance Enhancement
  • Injury Recovery


[table id=Brosceince1 /]

(Smith-Ryan, A., & Antonio, J. 2013)


  • Caloric intake – body weight losses of 0.5% to 1%/week to maximize muscle retention
  • 2.3-3.1 g protein/kg BW of lean body mass per day
  • 15-30% of calories from fat
  • Remainder of calories from carbohydrate (Low Glycemic)
  • Three to six meals per day with a meal containing 0.4-0.5 g protein/kg BW before and after resistance training

(Helms, E. R. et al. 2014)



The gut microbiota is intimately tied into the digestive system and immune system as well as immune signaling to a variety of organs and systems.

When it come to exercise, GI health helps regulate adaptations to exercise.

Supplementation with probiotics in athletes has been shown to reduce the frequency, severity and duration of respiratory and gastrointestinal illness

Probiotics Sources: Yogurt, kombucha, kefir, fermented foods

(Lopez, R. M. et al. 2015) (Pyne, D. B., et al. 2015)


  • May improve athletic performance if deficient
  • Peak athletic performance when serum 25(OH)D levels approach 50 ng/mL. Ideal levels may be above 50 ng/mL
  • Optimum levels may protect the athlete from several acute and chronic medical conditions
  • Should you supplement? Consider your diet, geography, time of year, sun exposure.

Visit here for more information on Vitamin D.

(Cannell, J. J., et al. 2009)


  • 2-3% fluid loss adversely affects performance
  • Consider urine color
  • Hydrate before, during and after exercise
  • Encourage intake before thirst
  • After exercise, replenish to sweat losses
  • Monitor Pre/Post exercise weight

Both coconut water and bottled water provide similar rehydrating effects as compared to a carbohydrate-electrolyte sport drinks

(Antonio, J. et al. 2009) (Kalman, D. S. et al. 2012) (Smith-Ryan, A., & Antonio, J. 2013)


[table id=2 /]

(Maridakis, V. et al. 2007) (McNaughton, L. R. et al. 2008) (Smith-Ryan, A., & Antonio, J. 2013)


Coffee= Ergogenic aid with additional benefits.

Caffeine, chlorogenic acid and other phytochemicals found in coffee are synergistic for performance enhancement and health promotion.

Health Benefits:
  • Diabetes mellitus
  • Various cancers
  • Parkinson’s and Alzheimer’s
  • Oxidative stress
  • Cognitive functionality
  • NAFLD (Non-Alcoholic Fatty Liver Disease)

(Butt, M. S., & Sultan, M. T. 2011)


[table id=3 /]

(Black, C. D. et al. 2010) (Connolly, D. A. J. et al. 2006)  (Davis, J. M. et al. 2007) (Saunders, M. J. 2011)  (Smith-Ryan, A., & Antonio, J. 2013)   (Tarazona-Díaz, M. P. 2013)


Consumption of the supplements are usually suggested into 5 specific times:

  1. Pre-exercise (nitrate, caffeine, sodium bicarbonate, carbohydrate and protein)
  2. During exercise (carbohydrate)
  3. Post-exercise (creatine, carbohydrate, protein)
  4. Meal time (β-alanine, creatine, sodium bicarbonate, nitrate, carbohydrate and protein)
  5. Before sleep (protein)

The recommended dosing protocol for the supplements nitrate and β-alanine are fixed amounts irrespective of body weight. Dosing protocol for sodium bicarbonate, caffeine and creatine supplements are related to corrected body weight (mg/kg bw).

Intake duration is suggested for creatine and β-alanine, being effective in chronic daily time < 2 weeks, while caffeine, sodium bicarbonate are effective in acute daily time (1-3 hours). Ingestion of nitrate supplement is required in both chronic daily time < 28 days and acute daily time (2- 2.5 h) prior exercise.

Supplement Timing Summary

Β-alanine: 3-6 g along with each meal containing carbohydrate and protein plus a dose of 1.2 g as a maintenance dose following acute β-alanine supplementation.

Nitrate-rich beetroot juice: 140 ml (8.4 mmol) containing nitrate, 2-3 h prior to middle distance and endurance exercise

Sodium Bicarbonate: 300-500 mg/Kg bw, 60-180 min prior to exercise, 1-3 days.

Caffeine: 3-6 mg/(kg bw), 30- 60 min prior to exercise

Creatine monohydrate: Daily intakes of 3-5 g, or for optimal absorption, 20 g divided into 4 daily intakes of 5 g in combination with carbohydrate and protein

Carbohydrate supplementation before exercise is essential to improve exercise performance. It is suggested that 1-4 g/kg carbohydrate is needed 1-4 h before exercise. In addition, carbohydrate mouth rinse can improve exercise performance (~2-3%) mediated by receptors in the oral cavity and the brain, during exercise lasting less than 60 min. When the exercise duration is more than 60 min, the advice is to ingest 90 g/h of mixed carbohydrates (60 g/ h glucose plus 30 g/h fructose). This is important during prolonged endurance events of 3 hours or more, and, 1.2 g/kg/h carbohydrate is required for glycogen repletion immediately post exercise.

Protein should be ingested in each main meal, immediately post exercise, and also before sleeping with an amount of 20-25 g for stimulating muscle protein synthesis.

(Naderi, A. et al. 2016)


While not an ergogenic aid, a multivitamin/mineral can help fill in the gaps and serve as a nutritional insurance policy, especially if your diet is not optimum.



  • Does it apply to my client/sport?
  • Causality or correlation?
  • Are the results overstated?
  • Conflict of interest?
  • Research bias/agenda?
  • Peer-reviewed journal?
  • Who was studied and where?
  • Sample size?
  • Controlled?
  • Acknowledgement of limitations?
  • Can the statistical significance be extrapolated to real life circumstances


  • Quality Assurance- GMP facility- same standards required by pharmaceutical companies
  • Certificate of Analysis (COA) for ingredients. Tested by an independent lab
  • NSF certified- third-party quality assurance
  • Transparent Labeling- all ingredients are listed. Watch out for proprietary formulas
  • Opt for capsules. Pill forms need binders or coatings
  • Avoid products that contain sucrose, artificial colors or flavors, or hydrogenated oils
  • Therapeutic dose
  • Avoid “kitchen sink” supplements
  • Clinical studies
  • Cost/Value- are you paying for marketing or research
  • Standardized Herbal Extracts vs Whole Herbs
  • Company reputation



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Black, C. D., Herring, M. P., Hurley, D. J., & O’Connor, P. J. (2010). Ginger (Zingiber officinale) reduces muscle pain caused by eccentric exercise. The Journal of Pain11(9), 894-903.

Burke, Louise M., Gregory R. Cox, Nicola K. Cummings, and Ben Desbrow. “Guidelines for daily carbohydrate intake.” Sports medicine 31, no. 4 (2001): 267-299.

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Cabrera, C., Artacho, R., & Giménez, R. (2006). Beneficial effects of green tea—a review. Journal of the American College of Nutrition25(2), 79-99.

Cannell, J. J., Hollis, B. W., Sorenson, M. B., Taft, T. N., & Anderson, J. J. (2009). Athletic performance and vitamin D. Med Sci Sports Exerc, 41(5), 1102-1110.

Clark, M. A., Lucett, S., & Corn, R. J. (2008). NASM essentials of personal fitness training. Lippincott Williams & Wilkins.

Connolly, D. A. J., McHugh, M. P., & Padilla-Zakour, O. I. (2006). Efficacy of a tart cherry juice blend in preventing the symptoms of muscle damage. British Journal of Sports Medicine40(8), 679-683.

Davis, J. M., Murphy, E. A., Carmichael, M. D., Zielinski, M. R., Groschwitz, C. M., Brown, A. S., … & Mayer, E. P. (2007). Curcumin effects on inflammation and performance recovery following eccentric exercise-induced muscle damage. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology292(6), R2168-R2173.

Dreyer, H. C., Drummond, M. J., Pennings, B., Fujita, S., Glynn, E. L., Chinkes, D. L., … & Rasmussen, B. B. (2008). Leucine-enriched essential amino acid and carbohydrate ingestion following resistance exercise enhances mTORsignaling and protein synthesis in human muscle. American Journal of Physiology-Endocrinology And Metabolism294(2), E392-E400.

Driskell, J. E., Copper, C., & Moran, A. (1994). Does mental practice enhance performance?. Journal of applied psychology79(4), 481.

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González-Garrido, J. A., García-Sánchez, J. R., Garrido-Llanos, S., & Olivares-Corichi, I. M. (2015). An association of cocoa consumption with improved physical fitness and decreased muscle damage and oxidative stress in athletes. The Journal of sports medicine and physical fitness.

Helms, E. R., Aragon, A. A., & Fitschen, P. J. (2014). Evidence-based recommendations for natural bodybuilding contest preparation: nutrition and supplementation. Journal of the International Society of Sports Nutrition,11(1), 1.

Kalman, D. S., Feldman, S., Krieger, D. R., & Bloomer, R. J. (2012). Comparison of coconut water and a carbohydrate-electrolyte sport drink on measures of hydration and physical performance in exercise-trained men.Journal of the International Society of Sports Nutrition, 9(1), 1.

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MacLean, C. R., Walton, K. G., Wenneberg, S. R., Levitsky, D. K., Mandarino, J. P., Waziri, R., … & Schneider, R. H. (1997). Effects of the transcendental meditation program on adaptive mechanisms: changes in hormone levels and responses to stress after 4 months of practice. Psychoneuroendocrinology22(4), 277-295.

Mah, C. D., Mah, K. E., Kezirian, E. J., & Dement, W. C. (2011). The effects of sleep extension on the athletic performance of collegiate basketball players. Sleep34(7), 943-950.

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Murase, T., Haramizu, S., Shimotoyodome, A., Tokimitsu, I., & Hase, T. (2006). Green tea extract improves running endurance in mice by stimulating lipid utilization during exercise. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology290(6), R1550-R1556.

Naderi, A., de Oliviera, E. P., Ziegenfuss, T. N., & Willems, M. E. (2016). Timing, optimal dose and intake duration of dietary supplements with evidence-based uses in sports nutrition. Journal of Exercise Nutrition & Biochemistry.

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